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2385s  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc 2385s
    2385s, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 137 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/2385s/product/Cell Signaling Technology Inc
    Average 95 stars, based on 137 article reviews
    2385s - by Bioz Stars, 2026-06
    95/100 stars

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    Pharmacophore construction for HIF2α inhibitors. The pharmacophore model of the active site within HIF2α was developed by means of the pharmacophore editor. It encompassed these pharmacophore features: F1:Aro (Aromatic centre, orange), F2:Aro and F3:Hyd (Hydrophobic centroid, green). The pharmacophore features were depicted in the form of spheres. The PT2385 was colour-coded by yellow. The oxygen atoms were red, and nitrogen atoms were blue.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Identification of novel HIF2α inhibitors: a structure‐based virtual screening approach

    doi: 10.1080/14756366.2025.2606435

    Figure Lengend Snippet: Pharmacophore construction for HIF2α inhibitors. The pharmacophore model of the active site within HIF2α was developed by means of the pharmacophore editor. It encompassed these pharmacophore features: F1:Aro (Aromatic centre, orange), F2:Aro and F3:Hyd (Hydrophobic centroid, green). The pharmacophore features were depicted in the form of spheres. The PT2385 was colour-coded by yellow. The oxygen atoms were red, and nitrogen atoms were blue.

    Article Snippet: The PT2385 (CAS number: 1672665-49-4) was purchased from MedChemExpress (Monmouth Junction, NJ, USA).

    Techniques:

    The calculated binding free energies of Compounds 1–6 and PT2385. Significance: ** p < 0.01, and *** p < 0.001.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Identification of novel HIF2α inhibitors: a structure‐based virtual screening approach

    doi: 10.1080/14756366.2025.2606435

    Figure Lengend Snippet: The calculated binding free energies of Compounds 1–6 and PT2385. Significance: ** p < 0.01, and *** p < 0.001.

    Article Snippet: The PT2385 (CAS number: 1672665-49-4) was purchased from MedChemExpress (Monmouth Junction, NJ, USA).

    Techniques: Binding Assay